Pemphigus

Pemphigus is not a common condition; in some cases, this is in fact a fatal disease, where bullae (blisters) of different sizes, break out on the penis Pemphigus covering, skin, the vagina, mouth lining, and other membranes.

Pemphigus develops most frequently in elderly or middle age individuals. Pemphigus rarely develops in children. The disease is resulted from autoimmune attacks against epidermal cell surfaces structures that maintain tissue texture, and cell-to-cell contact. Pemphigus hallmarks are clear fluid-filled, soft various sizes blisters; in some pemphigus types the scaly patches may appear.

Slight rubbing or pinching can easily detach the skin’s surfaces from the lower layers. Bullae (blisters) usually appear first first in the mouth and then rupture, producing painful ulcers. More ulceration and blistering can follow until entire mouth lining is damaged.¬† It is important to know, the blisters form over apparently healthy skin, then rupture, leaving crusted, raw wounds. The blister can be widespread, and when ruptured, it can become infected.

Diagnosis of Pemphigus consists of immune skin testing of a specimen for antibody deposits and regular microscopic evaluation. The main treatment goal is to stop new blisters (bullae) from forming. Immune system’s partial suppression with corticosteroids medications, such as prednisone used orally, is most likely to achieve such goal, but the body may become more susceptible to infections.

Generally, for the first seven to ten days, the corticosteroid is prescribed at a high dose. After that, the dosage is gradually decreased. To keep the Pemphigus under control, an individual can be required to use this medication for few months or years. Other medications suppressing the person’s immune system, including gold salts methotrexate, azathioprine and cyclophosphamide, can be prescribed, so that the dose of corticosteroid¬† medication may be reduced. Such strong medications have side effects as well, however, immunosuppressant medications can also be taken together with a process, where antibodies are filtered from the person’s blood, called plasmapheresis.

Antibiotics and other medications may be necesarry to treat ruptured blister infections. Dressings containing vaseline, such as petroleum jelly, or other dressing types, may protect oozing, raw areas.

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