Amyloidosis

Amyloidosis is a medical condition, where amyloid, an unusual protein, that usually is not present in the person’s body, accumulates in different tissues. Various types of Amyloidosis Amyloidosis Amyloidosisexists.

In primary Amyloidosis, the causes are unknown. However, it is associated with plasma cells’ abnormalities, as is multiple myelomas, which can also be associated with Amyloidosis. In secondary Amyloidosis, the Amyloidosis is secondary to such diseases as granulomatous ileitis, tuberculosis, familial Mediterranean Fever, rheumatoid arthritis, and bone infection.

Another type of Amyloidosis is hereditary Amyloidosis, which affects specific organs and nerves; it is usually occur in persons from Japan, Sweden, Portugal, and other countries. Other Amyloidosis’s type is associated with aging and especially affects the person’s heart. The cause of excessive amyloid’s build up is unknown. However, Amyloidosis may be a reaction to the different diseases that result in chronic inflammation or injections. Yet another Amyloidosis form is associated with Alzheimer’s disease.

The large amyloid amount accumulation may disturb many organs’ normal functioning. Amyloidosis symptoms depend on where the amyloid builds up. Many patients experience few symptoms, while others progressing life threatening severe disease. In primary Amyloidosis, specific amyloid buildup sites are the blood vessels, heart, kidney, lungs, liver, skin, intestine, tongue and thyroid gland. An amyloid accumulation may lead to kidney failure, heart failure, easy bruising, irregular heartbeat, liver failure, breathing difficulty, poor absorption of food, an underactive thyroid gland, and thickened tongue.

Nerves can malfunction, causing abnormal sensations and weakness. Carpal Tunnel Syndrome can progress. If amyloid affects the person’s heart, death can occur because of irregular heartbeat or severe heart failure. In secondary Amyloidosis, amyloid is usually building up in the lymph nodes, spleen, adrenal glands, kidney, and liver. The liver and spleen tend to enlarge and to feel rubbery and firm to the physician who examines them. Blood vessels and other organs can also be damaged, although, the heart involved rarely.

Diagnosis of Amyloidosis, in some cases, is difficult to make, because it produces too many different problems. However, a doctor can suggest Amyloidosis when a patient bleeds easily without no reason or when few organs fail. The hereditary Amyloidosis is suggested, when an inherited disorder of the peripheral nerve is found in the family. Amyloidosis’ diagnosis is usually made by examining a tiny abdominal fat amount, taken through a needle placed near the navel. The doctor may obtain a tissue sample for biopsy from the liver, skin, kidney, gums, or rectum.

The amyloid is visible under the microscope with the use of specific strains. Amyloidosis does not always need treatment. if Amyloidosis is resulted from another disorder, treating the other disorder usually reverses or slows the Amyloidosis. However, if Amyloidosis is resulted from multiple myeloma, the Amyloidosis has a poor prognosis; most patients with both diseases die within one or two years.

Amyloidosis treatment has not been very successful. The patient can find relief by using Melphalan and Prednisone, sometimes, with Colchicine. Colchicine alone can help to relieve Amyloidosis, caused by Mediterranean fever. Amyloid tumor (amyloid accumulation) in a certain parts of the body sometimes requires surgical removal. The patients with destroyed kidneys, caused by Amyloidosis, can receive a kidney transplant. Some patients, who have heart disorders, can receive a heart transplant. However, the transplanted organ can later become affected by the amyloid buildup. In the hereditary Amyloidosis form, the amyloid-producing abnormality happens in the patient’s liver; only few individuals have had successful transplant of the liver to stop progression of the disease.

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